Assign ESMO 2016

Assign ESMO 2016 based on stage, grade, histological subtype group, myometrial invasion, and LVSI. Residual disease can be used if available.

assign_esmo2016(stage_full, grade, hist_gr, myo, lvi, residual = NULL)

Arguments

stage_full

FIGO stage: I, II, III, IV with substages

grade

tumour grade: 1, 2, 3

hist_gr

histological subtype group: endometrioid or non-endometrioid

myo

myometrial invasion: none, 1-50%, >50%

lvi

lymphovascular space invasion: negative, positive, focal, extensive

residual

residual disease: "<1cm", ">=1cm", "microscopic", or "no residual". Use if available. Microscopic residual is regarded as no residual disease.

Value

ESMO 2016 assigned into "low", "intermediate", "high-intermediate", "high", "advanced", or "metastatic". Unassignable cases are NA.

Details

ESMO 2016 is assigned using stage, grade, histological subtype group, myometrial invasion, and LVSI into low, intermediate, high-intermediate, high, advanced, and metastatic risk based on the following criteria:

• low:

  • stage I, grade 1/2, endometrioid, <50% myometrial invasion, LVSI negative

• intermediate:

  • stage I, grade 1/2, endometrioid, >=50% myometrial invasion, LVSI negative

• high-intermediate:

  • stage I, grade 3, endometrioid, <50% myometrial invasion, regardless of LVSI status

  • stage I, grade 1/2, endometrioid, LVSI unequivocally positive, regardless of depth of invasion

• high:

  • stage I, grade 3, endometrioid, >=50% myometrial invasion, regardless of LVSI status

  • stage II or higher

  • stage III, endometrioid, (no residual disease if known)

  • non-endometrioid (serous or clear-cell or undifferentiated carcinoma, or carcinosarcoma), (no residual disease if known)

• advanced:

  • stage III, (with residual disease if known)

  • stage IVA

• metastatic:

  • stage IVB

Note

Assignment starts from the metastatic group first as the criteria are not mutually exclusive.

References

Colombo et al. Annals of Oncology 2016

Author

Derek Chiu, Samuel Leung

Examples

esmo2016 <- with(emdb, assign_esmo2016(stage_full, grade_rev, hist_rev_gr,
myo, lvi, residual))
table(esmo2016)
#> esmo2016
#>               low      intermediate high-intermediate              high 
#>                36                21                99               398 
#>          advanced        metastatic 
#>                35                 6