Assign MMR status by 4 IHC markers

Assign MMR status by 4 IHC markers, MSH6, PMS2, MLH1, and MSH2.

assign_mmr4(msh6, pms2, mlh1, msh2)

Arguments

msh6

MSH6 marker

pms2

PMS2 marker

mlh1

MLH1 marker

msh2

MSH2 marker

Value

MMR status, either "intact" or "deficient"

Details

MMR status, intact or deficient, is determined by IHC markers MSH6, PMS2, MLH1, and MSH2 consolidated from TMA scoring. If all markers are intact, then MMR status is intact. Otherwise, MMR status is deficient (including subclonal and unknown markers).

Author

Samuel Leung, Derek Chiu

Examples

mmr_ihc_4 <- with(emdb, assign_mmr4(msh6, pms2, mlh1, msh2))
table(mmr_ihc_4)
#> mmr_ihc_4
#> deficient    intact 
#>       546       133