Assign MMR status by 4 IHC markers — assign

Assign MMR status by 4 IHC markers, MSH6, PMS2, MLH1, and MSH2.

assign_mmr4(msh6, pms2, mlh1, msh2)

Arguments

msh6: MSH6 marker
pms2: PMS2 marker
mlh1: MLH1 marker
msh2: MSH2 marker

Value

MMR status, either "intact" or "deficient"

Details

MMR status, intact or deficient, is determined by IHC markers MSH6, PMS2, MLH1, and MSH2 consolidated from TMA scoring. If all markers are intact, then MMR status is intact. Otherwise, MMR status is deficient (including subclonal and unknown markers).

Author

Samuel Leung, Derek Chiu

Examples

mmr_ihc_4 <- with(emdb, assign_mmr4(msh6, pms2, mlh1, msh2))
table(mmr_ihc_4)
#> mmr_ihc_4
#> deficient    intact 
#>       546       133