Assign Poor-man's ProMisE

Assign Poor-man's ProMisE based on POLE, MMR, p53, and histopathological features.

assign_promisepoor(mmr_ihc_2, mmr_ihc_4, pole_mut, p53, grade, hist_gr)

Arguments

mmr_ihc_2

MMR status determined by 2 IHCs: MSH6 and PMS2

mmr_ihc_4

MMR status determined by 4 IHCs: MSH6, PMS2, MLH1, and MSH2

pole_mut

POLE mutation status

p53

p53 IHC

grade

tumour grade: 1, 2, 3

hist_gr

histological subtype group: endometrioid or non-endometrioid

Value

Poor-man's ProMisE assigned into "Low-Risk", "POLEmut", "MMRd", "p53abn", or "NSMP/p53wt"

Details

Poor-man's ProMisE first assigns a low risk group based on histopathological features grade, histotype, MMR status determined by 2 and 4 IHC markers, and p53. The rest of the high risk cases are assigned as in ProMisE 2019.

Author

Derek Chiu, Samuel Leung

Examples

promisepoor <- with(emdb, assign_promisepoor(mmr_ihc_2, mmr_ihc_4, pole_mut,
p53, grade_rev, hist_rev_gr))
table(promisepoor)
#> promisepoor
#>   Low-Risk    POLEmut       MMRd     p53abn NSMP/p53wt 
#>        120         52        142        102        253